Kurang Tidur dan Regulasi Nafsu Makan: Tinjauan Mekanisme Hormonal dan Metabolik

Rossy Triana; Desak Ketut Indrasari Utami

doi:10.56951/wt0v0274

Kurang Tidur dan Regulasi Nafsu Makan: Tinjauan Mekanisme Hormonal dan Metabolik

Penulis

Rossy Triana Departemen Neurologi, Fakultas Kedokteran, Universitas Udayana/RSUP Prof. dr. I.G.N.G. Ngoerah, Denpasar, Bali, Indonesia
Desak Ketut Indrasari Utami Departemen Neurologi, Fakultas Kedokteran, Universitas Udayana/RSUP Prof. dr. I.G.N.G. Ngoerah, Denpasar, Bali, Indonesia

DOI:

https://doi.org/10.56951/wt0v0274

Kata Kunci:

kurang tidur, nafsu makan, metabolisme, obesitas, resistansi insulin

Abstrak

Kurang tidur telah menjadi masalah kesehatan global yang semakin sering dijumpai di era modern. Kondisi ini tidak hanya berdampak pada fungsi kognitif dan kualitas hidup, tetapi juga berhubungan erat dengan regulasi nafsu makan
dan metabolisme. Berbagai penelitian menunjukkan bahwa deprivasi tidur memicu perubahan hormonal, termasuk peningkatan grelin, penurunan leptin, serta gangguan keseimbangan hormon lain yang berperan dalam regulasi rasa lapar dan kenyang. Dampak fisiologis ini mendorong peningkatan asupan energi, terutama dari makanan tinggi kalori, serta
memperlemah kontrol kognitif terhadap dorongan makan. Selain itu, kurang tidur terbukti menurunkan sensitivitas insulin, meningkatkan resistansi insulin, serta mengganggu homeostasis glukosa, sehingga berkontribusi pada risiko obesitas, diabetes tipe 2, serta sindrom metabolik. Dengan demikian, tidur yang cukup dan berkualitas memiliki peran penting dalam menjaga keseimbangan metabolik dan mencegah terjadinya gangguan kesehatan jangka panjang.

Unduhan

Baca Selengkapnya

Referensi

1. Sheehan CM, Frochen SE, Walsemann KM, Ailshire JA. Are US adults reporting less sleep?: Findings from sleep duration trends in the National Health Interview Survey, 2004–2017. Sleep. 2019;42(2):zsy221. doi:10.1093/sleep/zsy221.

2. Bixler E. Sleep and society: an epidemiological perspective. Sleep Med. 2009;10(Suppl 1):S3-S6. doi:10.1016/j.sleep.2009.07.005.

3. Liu Y, Wheaton AG, Chapman DP, Cunningham TJ, Lu H, Croft JB. Prevalence of healthy sleep duration among adults—United States, 2014. MMWR Morb Mortal Wkly Rep. 2016;65(6):137-141. doi:10.15585/mmwr.mm6506a1.

4. Liu S, Wang X, Zheng Q, Gao L, Sun Q. Sleep deprivation and central appetite regulation. Nutrients. 2022;14(24):5196. doi:10.3390/nu14245196.

5. Schmid SM, Hallschmid M, Jauch-Chara K, Wilms B, Benedict C, Lehnert H, et al. Short-term sleep loss decreases physical activity under free-living conditions but does not increase food intake under time-deprived laboratory conditions in healthy men. Am J Clin Nutr. 2009;90(6):1476-1482. doi:10.3945/ajcn.2009.27984.

6. Tasali E, Leproult R, Ehrmann DA, Van Cauter E. Slow-wave sleep and the risk of type 2 diabetes in humans. Proc Natl Acad Sci U S A. 2008;105(3):1044-1049. doi:10.1073/pnas.0706446105.

7. Deboer T. Sleep homeostasis and the circadian clock: Do the circadian pacemaker and the sleep homeostat influence each other's functioning? Neurobiol Sleep Circadian Rhythms. 2018;5:68-77. doi:10.1016/j.nbscr.2018.02.003.

8. Husse J, Kiehn JT, Barclay JL, Naujokat N, Meyer-Kovac J, Lehnert H, et al. Tissue-specific dissociation of diurnal transcriptome rhythms during sleep restriction in mice. Sleep. 2017;40(6):zsx068. doi:10.1093/sleep/zsx068.

9. Spiegel K, Tasali E, Leproult R, Scherberg N, Van Cauter E. Twenty-four-hour profiles of acylated and total ghrelin: relationship with glucose levels and impact of time of day and sleep. J Clin Endocrinol Metab. 2011;96(2):486-493. doi:10.1210/jc.2010-1978.

10. Simon C, Gronfier C, Schlienger JL, Brandenberger G. Circadian and ultradian variations of leptin in normal man under continuous enteral nutrition: relationship to sleep and body temperature. J Clin Endocrinol Metab. 1998;83(6):1893-1899. doi:10.1210/jcem.83.6.4864.

11. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92(4):573-585. doi:10.1016/S0092-8674(00)80949-6.

12. Mohammadi S, Moosaie F, Saghazadeh A, Mahmoudi M, Rezaei N. Metabolic profile in patients with narcolepsy: a systematic review and meta-analysis. Sleep Med. 2021;81:268-284. doi:10.1016/j.sleep.2021.02.040.

13. Chaput JP, Bouchard C, Tremblay A. Change in sleep duration and visceral fat accumulation over 6 years in adults. Obesity. 2014;22(5):E9-E12. doi:10.1002/oby.20701.

14. Xie J, Li Y, Zhang Y, Vgontzas AN, Basta M, Chen B, et al. Sleep duration and metabolic syndrome: An updated systematic review and meta-analysis. Sleep Med Rev. 2021;59:101451. doi:10.1016/j.smrv.2021.101451.

15. Duan D, Kim LJ, Jun JC, Polotsky VY. Connecting insufficient sleep and insomnia with metabolic dysfunction. Ann N Y Acad Sci. 2023;1519(1):94-117. doi:10.1111/nyas.14926.

16. Nedeltcheva AV, Kilkus JM, Imperial J, Kasza K, Schoeller DA, Penev PD. Sleep curtailment is accompanied by increased intake of calories from snacks. Am J Clin Nutr. 2009;89(1):126-133. doi:10.3945/ajcn.2008.26574.

17. Benedict C, Brooks SJ, O'Daly OG, Almèn MS, Morell A, Åberg K, et al. Acute sleep deprivation enhances the brain's response to hedonic food stimuli: an fMRI study. J Clin Endocrinol Metab. 2012;97(3):E443-E447. doi:10.1210/jc.2011-2759.

18. Hanlon EC, Tasali E, Leproult R, Stuhr KL, Doncheck E, de Wit H, et al. Sleep restriction enhances the daily rhythm of circulating levels of endocannabinoid 2-arachidonoylglycerol. Sleep. 2016;39(3):653-664. doi:10.5665/sleep.5546.