Preeclampsia in the Modern Era: New Insights from Global Research and Implications for Practice in Indonesia

Arya Ady Nugroho; Yudianto Budi Saroyo; Allan Taufiq Rivai

doi:10.56951/v8ne8639

Preeclampsia in the Modern Era: New Insights from Global Research and Implications for Practice in Indonesia

Penulis

Arya Ady Nugroho Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Yudianto Budi Saroyo Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Allan Taufiq Rivai Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecologic, University of Indonesia Hospital, Depok, West Java, Indonesia

DOI:

https://doi.org/10.56951/v8ne8639

Kata Kunci:

preeklampsia, gangguan hipertensi kehamilan, disfungsi plasenta, biomarker angiogenik, profilaksis aspirin, kesehatan maternal di Indonesia

Abstrak

Preeklampsia (PE) masih menjadi penyebab utama morbiditas dan mortalitas maternal serta neonatal di seluruh dunia, yang memengaruhi 2–15% kehamilan. Tinjauan ini menyajikan sintesis kemajuan terkini dalam memahami patofisiologi
PE, termasuk disfungsi plasenta, gangguan endotel, dan biomarker baru seperti faktor angiogenik. Berdasarkan studi global yang diterbitkan hingga tahun 2025, kami mengeksplorasi model prediksi untuk deteksi dini sebelum usia kehamilan 11 minggu, strategi manajemen inovatif seperti profilaksis aspirin, dan disparitas luaran maternal dan neonatal. Di
Indonesia, di mana PE berkontribusi terhadap 26–30% kematian maternal, kami menyoroti epidemiologi lokal, faktor risiko seperti anemia dan obesitas, serta intervensi yang disesuaikan untuk meningkatkan skrining dan perawatan di layanan
dengan sumber daya terbatas. Dengan menekankan praktik berbasis bukti, artikel ini menegaskan perlunya pendekatan terintegrasi untuk mengurangi beban PE serta memberikan wawasan yang dapat ditindaklanjuti bagi klinisi dalam konteks Indonesia maupun global.

Unduhan

Baca Selengkapnya

Referensi

1. Karrar SA, Martingano DJ, Hong PL. Preeclampsia. [Updated 2024 Feb 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK570611/

2. Gurnani N, et al. Hypertensive disorders of pregnancy: innovative management approaches. JACC Adv. 2024;3(4):100864. doi:10.1016/j.jacadv.2024.100864.

3. Vera-Ponce VJ, Loayza-Castro JA, Ballena-Caicedo J, et al. Global prevalence of preeclampsia, eclampsia, and HELLP syndrome: a systematic review and meta-analysis. Front Reprod Health. 2025 Nov 10;7:1706009. doi:10.3389/frph.2025.1706009. PMID: 41293035; PMCID: PMC12640961.

4. Countouris M, Mahmoud Z, Cohen JB, et al. Hypertension in Pregnancy and Postpartum: Current Standards and Opportunities to Improve Care. Circulation. 2025 Feb 18;151(7):490-507. doi:10.1161/CIRCULATIONAHA.124.073302. Epub 2025 Feb 17. PMID: 39960983; PMCID: PMC11973590.

5. Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: pathophysiology, challenges, and perspectives. Circ Res. 2019;124(7):1094-1112. doi:10.1161/CIRCRESAHA.118.313276.

6. Chamilard M, Diaz V, Gialdini C, Pasquale J, Portela A, Abalos E. Similarities and differences in international clinical practice guidelines for preeclampsia diagnosis and diagnostics: a scoping review. Hypertens Pregnancy. 2025;44(1):2532489. doi:10.1080/10641955.2025.2532489.

7. Kovacheva VP, Venkatachalam S, Pfister C, Anwer T. Preeclampsia and eclampsia: enhanced detection and treatment for morbidity reduction. Best Pract Res Clin Anaesthesiol. 2024;38(3):246-56. doi:10.1016/j.bpa.2024.11.001.

8. Özcan M, Peker S. Preeclampsia prediction via machine learning: a systematic literature review. Health Syst (Basingstoke). 2024;14(3):208-22. doi:10.1080/20476965.2024.2435845.

9. Xiong Y, Chen J, Wu Y, Zhao P, Liao M, Guo J, et al. The effect of maternal pre-pregnancy body mass index on hypertensive disorders of pregnancy (HDP): a systematic review and dose-response metaanalysis of cohort studies involving 50 million pregnancies. EClinicalMedicine. 2025;86:103395. doi:10.1016/j.eclinm.2025.103395.

10. Erez O, Romero R, Jung E, Chaemsaithong P, Bosco M, Suksai M, et al. Preeclampsia and eclampsia: the conceptual evolution of a syndrome. Am J Obstet Gynecol. 2022;226(2S):S786-S803. doi:10.1016/j.ajog.2021.12.001.

11. Qin Z, Long Y. Immunological dysregulation in preeclampsia: pathogenesis and clinical implications. Int Immunopharmacol. 2025;163:115314. doi:10.1016/j.intimp.2025.115314.

12. Dewi KT. Prevalence and associated factors of severe preeclampsia among pregnant women. Bulletin of Inspiring Developments and Achievements in Midwifery. 2025;2(1):36-44. doi:10.69855/bidan. v2i1.152.

13. Oktarina O, Nantabah ZK, Nyoman J, Ristrini R, Hakim L, Ridwan W, et al. Risk factors for hypertension in pregnant women in Indonesia: a cross-sectional study. Asian Pacific Journal of Tropical Medicine. 2024;17(9):408-17. doi:10.4103/apjtm.apjtm_832_23.

14. Pratiwi R, Indriyani I, Putra RT. Trends in the initial management of severe preeclampsia and eclampsia in Indonesia: a medical record study (2018-2021). Innov Health Soc. 2024;4(2):101-109. doi:10.31603/ihs.12533.

15. Usman NA, Mappaware NA, Gunawan W. The determinant factors of preeclampsia incidence in pregnant women at Haji Hospital Makassar in 2024. Journal La Medihealthco. 2025;6(3):766-73. doi:10.37899/journallamedihealthco.v6i3.2280.

16. Rashidian P, Parsaei M, Hantoushzadeh S, Salmanian B. Investigating the association of albuminuria with the incidence of preeclampsia and its predictive capabilities: a systematic review and metaanalysis. BMC Pregnancy Childbirth. 2025;25(1):322. doi:10.1186/s12884-025-07444-z.