The Role of Hypocalcemia in Preeclampsia: A Review on Calcium Supplementation in Pregnancy
DOI:
https://doi.org/10.56951/3t90rn95Kata Kunci:
hypocalcemia, preeclampsia, vitamin D, pregnancy, hypertensionAbstrak
Abstract
Preeclampsia is a hypertensive disorder that contributes to the high maternal death rate worldwide. Furthermore, preeclampsia adversely affects fetal development due to reduced placental blood flow. Numerous factors are known to affect the development and pathophysiology of preeclampsia, one of them is micronutrient deficiency. Calcium, an essential mineral, plays a crucial role in the mechanism of vascular smooth muscle contraction, which regulates vascular tone and blood pressure. Placental dysfunction, a hallmark of preeclampsia, leads to hypocalcemia, which, in turn, exacerbates the condition through compensatory mechanisms involving parathyroid hormone. Conversely, adequate calcium intake has been proven beneficial and is recommended during pregnancy. This article aims to review current guidelines on calcium supplementation and nutritional recommendations as a viable strategy to minimize the risk of preeclampsia.
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Referensi
1. American College of Obstetricians and Gynecologists. Hypertension in pregnancy. Washington, DC: American College of Obstetricians and Gynecologists; 2013.
2. Karrar S, Hong PL. Preeclampsia [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK570611/
3. Perkumpulan Obstetri dan Ginekologi Indonesia, Himpunan Kedokteran Feto Maternal. Pedoman Nasional Pelayanan Kedokteran: Diagnosis dan Tata Laksana Preeklamsia. Indonesia; 2016.
4. Rokom. Agar ibu dan bayi selamat [Internet]. Sehat Negeriku. Redaksi Sehat Negeriku; 2024. Available from: https://sehatnegeriku.kemkes.go.id/baca/blog/20240125/3944849/agar-ibu-dan-bayi-selamat/
5. Rashid B, Richard MM, Gul-E-Rana LNU. Low serum calcium levels in preeclampsia. J South Asian Fed Obstet Gynaecol. 2015;7(3):126-9.
6. Ives CW, Sinkey R, Rajapreyar I, Tita ATN, Oparil S. Preeclampsia—pathophysiology and clinical presentations: JACC state-of-the-art review. J Am Coll Cardiol. 2020;76(14):1690-702.
7. Peacock M. Calcium metabolism in health and disease. Clin J Am Soc Nephrol. 2010;5(Suppl 1):S23-30.
8. Yu E, Sharma S. Physiology, calcium [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482128/
9. Goyal A, Singh S, Anastasopoulou C, Ngu M. Hypocalcaemia [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2020. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430912/
10. Ross AC, Taylor CL, Yaktine AL, Del Valle HB. Overview of calcium [Internet]. NIH.gov. National Academies Press (US); 2011. Available from: https://www.ncbi.nlm.nih.gov/books/NBK56060/
11. Almaghamsi A, Almalki MH, Buhary BM. Hypocalcaemia in pregnancy: a clinical review update. Oman Med J. 2018;33(6):453-62.
12. Prada JA, Ross R, Clark KE. Hypocalcaemia and pregnancy-induced hypertension produced by maternal fasting. Hypertension. 1992;20(5):620-6.
13. Khan S, Urooj U, Khan R, Noor N, Zohra S, Khan T. Role of calcium levels in pregnant women with preeclampsia and severe preeclampsia. Pak Armed Forces Med J. 2023;73(6).
14. Villa-Etchegoyen C, Lombarte M, Matamoros N, Belizán JM, Cormick G. Mechanisms involved in the relationship between low calcium intake and high blood pressure. Nutrients. 2019;11(5):1112.
15. Shah KH, Bhat S, Shetty S, Umakanth S. Hypoparathyroidism in pregnancy. BMJ Case Rep. 2015;bcr2015210228.
16. Lia NL, Sultana R, Zaman JA, Sultana F, Kheya AK. Urinary calcium creatinine ratio and association with preeclampsia. Anaesth Crit Care. 2024;6(3).
17. Gerovasili E, Sarantaki A, Bothou A, Deltsidou A, Dimitrakopoulou A, Diamanti A. The role of vitamin D deficiency in placental dysfunction: a systematic review. Metabolism Open. 2025;25:100350.
18. Shin JS, Choi MY, Longtine MS, Nelson DM. Vitamin D effects on pregnancy and the placenta. Placenta. 2010;31(12):1027-34.
19. World Health Organization. Guideline: calcium supplementation in pregnant women. Geneva: WHO; 2013.
20. American College of Obstetricians and Gynecologists. Nutrition during pregnancy [Internet]. ACOG; 2022. Available from: https://www.acog.org/womens-health/faqs/nutrition-during-pregnancy
21. Royal College of Obstetricians and Gynaecologists. Healthy eating and vitamin supplements in pregnancy [Internet]. UK: RCOG; 2022. Available from: https://www.rcog.org.uk/media/lcfn54fw/healthy-eating-vitamin-supplements-pregnancy-large-print-patient-information.pdf
22. Omotayo MO, Dickin KL, O’Brien KO, Neufeld LM, De Regil LM, Stoltzfus RJ. Calcium supplementation to prevent preeclampsia: translating guidelines into practice in low-income countries. Adv Nutr. 2016;7(2):275-8.
23. Tap L, Kirkham FA, Mattace-Raso FU, Joly L, Rajkumar C, Benetos A. Unraveling the links underlying arterial stiffness, bone demineralization, and muscle loss. Hypertension. 2020;76(3):629-39.
24. Apgar B. Comparison of common calcium supplements. Am Fam Physician. 2000;62(8):1895-6.
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