Pentingnya Mendeteksi Hiperammonia Transien pada Bayi Baru Lahir (Transient Hyperammonemia of the Newborn/THAN)

Juliani Dewi

doi:10.56951/me592623

Pentingnya Mendeteksi Hiperammonia Transien pada Bayi Baru Lahir (Transient Hyperammonemia of the Newborn/THAN)

Penulis

Juliani Dewi Spesialis Patologi Klinik, Laboratorium Rampal Diagnostika, Malang, Jawa Timur, Indonesia

DOI:

https://doi.org/10.56951/me592623

Kata Kunci:

amonia, bayi baru lahir, hiperamonemia, neurotoksik

Abstrak

Amonia merupakan produk sampingan metabolisme nitrogen. Pada individu sehat, amonia ditransportasikan dan dimetabolisme dengan regulasi yang ketat untuk menjaga konsentrasi dalam plasma tetap rendah. Peningkatan produksi
amonia atau insufisiensi detoksifikasi amonia dapat menyebabkan hiperamonemia. Hiperamonemia transien pada bayi
baru lahir (transient hyperammonemia of the newborn/THAN) sering kali tidak terdiagnosis, padahal dapat menyebabkan terjadinya koma dan kematian, terutama pada bayi prematur. Hiperamonemia akut adalah kondisi emergensi yang dapat menyebabkan edema serebri, kejang, koma, kerusakan neurologis berat, dan kematian. Kadar amonia dapat diukur menggunakan alat analisis otomatis maupun dry slide. Dengan deteksi dini dan penanganan yang cepat dan tepat,
prognosis THAN sangat baik, tanpa meninggalkan gejala sisa neurologis.

Unduhan

Baca Selengkapnya

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