The Use of Predimenol for Nonspecific, Mild-to-Moderate Headache: Case Series

Penulis

  • Rizaldy Taslim Pinzon Neurology Department, School of Medicine, Duta Wacana Christian University, Yogyakarta
  • Andre Darmawan Wiyono Neurology Department, School of Medicine, Duta Wacana Christian University, Yogyakarta

DOI:

https://doi.org/10.56951/s2zpt094

Kata Kunci:

headache, primary type, predimenol, high risk, NSAID

Abstrak

Headache is a major healthcare concern worldwide. Adequate headache management is a widespread clinical concern,
either using prescription or over-the-counter (OTC) nonsteroidal anti-inflammatory drugs (NSAIDs). The use of NSAIDs
for headache has been associated with several risk of cardiovascular (CV), renal, and gastrointestinal (GI) complications.
There were certain patients are at increased risk of using these agents. The use of NSAIDs results in small but consistent
increases in the risk of cardiovascular events and kidney problem. We report case series of primary headache conditions
with GI comorbidities. After careful history taking, neurological examination, and imaging, we used paracetamol and
Predimenol for one week. The use of Predimenol was effective in reducing headache severity without any significant side
effects. 

Referensi

1. Baraness L, Baker AM. Acute headache. [Updated 2023 Jul 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024.

2. May A. Hints on diagnosing and treating headache. Dtsch Arztebl Int. 2018;115(17):299–308.

3. Onderwater GLJ, van Dongen RM, Zielman R, Terwindt GM, Ferrari MD. Primary headaches. Handb Clin Neurol. 2017;146:267-84.

4. Murphy C, Hameed S. Chronic headaches. [Updated 2023 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024.

5. Pari E, Rinaldi F, Gipponi S, Venturelli E, Liberini P, Rao R, et al. Management of headache disorders in the emergency department setting. Neurol Sci. 2015;36(7):1153–60.

6. Ho KY, Cardosa MS, Chaiamnuay S, Hidayat R, Ho HQT, Kamil O, et al. Practice advisory on the appropriate use of NSAIDs in primary care. J Pain Res. 2020;13:1925–39.

7. Domper Arnal MJ, Hijos-Mallada G, Lanas A. Gastrointestinal and cardiovascular adverse events associated with NSAIDs. Expert Opin Drug Saf. 2022;21(3):373–84.

8. Ahmad R, Mazlan MKN, Aziz AFA, Gazzali AM, Rawa MSA, Wahab HA. Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological effects, toxicity studies, and separation techniques. Saudi Pharm J. 2023;31(6):874–88.

9. Olesen J. Nitric oxide-related drug targets in headache. Neurotherapeutics. 2010;7(2):183–90.

Diterbitkan

01-03-2025

Unduhan

Data unduhan tidak tersedia.

Cara Mengutip

[1]
The Use of Predimenol for Nonspecific, Mild-to-Moderate Headache: Case Series. MEDICINUS 2025;38:6-10. https://doi.org/10.56951/s2zpt094.