Terapi Terkini Pityriasis Rosea

Penulis

  • Riyanti Astrid Diahtantri Program Studi Dermatologi dan Venereologi Fakultas Kedokteran Universitas Indonesia/RSCM Jakarta
  • Aida SD Hoemardani Dermatologi dan Venereologi, Konsultan di RS Kanker Dharmais
  • Yudo Irawan Departemen Dermatologi dan Venereologi Fakultas Kedokteran Universitas Indonesia/RSCM Jakarta

DOI:

https://doi.org/10.56951/72h6tw89

Kata Kunci:

pityriasis rosea, terapi terkini

Abstrak

Pityriasis rosea (PR) merupakan erupsi kulit papuloskuamosa akut. Penyebab PR belum diketahui secara pasti, namun diduga akibat gangguan imunitas seluler atau infeksi HHV-6 dan HHV-7. Umumnya kondisi ini bersifat self-limiting disease dan akan mengalami pemulihan spontan dalam waktu beberapa minggu hingga bulan dengan pengobatan simtomatik topikal maupun sistemik. Penyakit ini relatif jarang mengalami kekambuhan. Dari keseluruhan kasus PR, terdapat beberapa kasus yang memerlukan terapi tambahan, seperti pada kasus lesi yang luas, pruritus berat, dan pasien yang dalam masa kehamilan. Tata laksana PR terbagi ke dalam tiga lini. Tata laksana lini pertama terdiri dari pemberian corticosteroid topikal, emolien, dan antihistamin oral. Lini kedua yaitu fototerapi narrow-band ultraviolet B (NBUVB) dan fototerapi ultraviolet A1 (UVA1). Kemudian lini ketiga terdiri dari terapi prednisone oral, erythromycin, acyclovir, dan dapsone.

Referensi

Clark M, Gudjonsson JE. Pityriasis rosea. In: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, et al., editor. Fitzpatrick’s Dermatology. 9th edition. New York: McGraw-Hill; pp. 518–24.

Drago F, Broccolo F, Rebora A. Pityriasis rosea: an update with a critical appraisal of its possible herpesviral etiology. J Am Acad Dermatol. 2009;61(2):303–18.

Data Kunjungan Poliklinik Kulit dan Kelamin, Unit Rawat Jalan Terpadu RSUPN dr. Cipto Mangunkusumo. 2018.

Neoh CY, Tan AWH, Mohamed K, Sun YJ, Tan SH. Characterization of the inflammatory cell infiltrate in herald patches and fully developed eruptions of pityriasis rosea. Clin Exp Dermatol. 2010;35(3):300–4.

Villalon-Gomez JM. Pityriasis rosea: diagnosis and treatment. Am Fam Physician. 2018;97(1):38-44.

Watanabe T, Kawamura T, Aquilino EA, Blauvelt A, Jacob SE, Orenstein JM, et al. Pityriasis rosea is associated with systemic active infection with both human herpesvirus-7 and human herpesvirus-6. J Invest Dermatol. 2002;119(4):793–7.

Drago F, Ciccarese G, Broccolo F, Ghio M, Contini P, Thanasi H, et al. The role of cytokines, chemokines, and growth factors in the pathogenesis of pityriasis rosea. Mediators Inflamm. 2015;2015:1–6.

Mahajan K, Relhan V, Relhan AK, Garg VK. Pityriasis rosea: an update on etiopathogenesis and management of difficult aspects. Indian J Dermatol. 2016;61(4):375–84.

Roxo R, Miranda C, Souza T, Gonzaga C, Azevedo L, Miranda M. Lysine for pityriasis rosea: is it a new treatment option? J Am Acad Dermatol. 2018;79(3):184.

Anna E M. Pityriasis rosea. In: Lebwohl MG, Heyman WR, Beth-Jones J, Colson I, editor. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. 5th edition. Amsterdam: Elsevier; 2018; pp.2132-9.

Kwatra SG, Loss M. Other topical medications. In: Kang S, Amagai M, Bruckner AL, Enk AH, Margolis DJ, McMichael AJ, Orringer JS, editor. Fitzpatrick’s Dermatology. 9th edition. New York: McGraw-Hill; 2019. pp. 3610–22.

Mak MF, Li W, Mahadev A. Calamine lotion to reduce skin irritation in children with cast immobilisation. J Orthop Surg. 2013;21(2):221–5.

Sethi A, Kaur T, Malhotra S, Gambhir M. Moisturizers: The slippery road. Indian J Dermatol. 2016;61(3):279.

Schwartz RA. Pityriasis rosea [Internet]. Medscape. 2021 [cited 20 September 2021]. Available at: https://emedicine.medscape.com/article/1107532-overview.

Drago F, Vecchio F, Rebora A. Use of high-dose acyclovir in pityriasis rosea. J Am Acad Dermatol. 2006;54(1):82–5.

Katzung BG, editor. Antiviral Agents. In: Katzung BG, Masters SB, Trevor AJ, editor. Basic & Clinical Pharmacology. 14th edition. New York: McGraw-Hill; 2018. pp. 863–94.

Widaty S, Soebono H, Nilasari H, Listiawan MY, Siswati A, Triwahyudi D, et al., editor. Panduan Praktik Klinis. Jakarta: PERDOSKI; 2017. pp. 34–5

Dinos GP. The macrolide antibiotic renaissance: the present and future of macrolide antibiotics. Br J Pharmacol. 2017;174(18):2967–83.

Sharma P, Yadav T, Gautam R, Taneja N, Satyanarayana L. Erythromycin in pityriasis rosea: a double-blind, placebo-controlled clinical trial. J Am Acad Dermatol. 2000;42(2):241– 4.

Rasi A, Tajziehchi L, Savabi-Nasab S. Oral erythromycin is ineffective in the treatment of pityriasis rosea. J Drugs Dermatol. 2008;7(1):35–8.

Ahmed N, Iftikhar N, Bashir U, Rizvi SDA, Sheikh ZI, Manzur A. Efficacy of clarithromycin in pityriasis rosea. J Coll Physicians Surg Pak. 2014;24:5.

Ehsani A, Esmaily N, Noormohammadpour P, Toosi S, Hosseinpour A, Hosseini M, et al. The comparison between the efficacy of high dose acyclovir and erythromycin on the period and signs of pityriasis rosea. Indian Journal of Dermatology. 2010;55(3):246–8.

Acharya A, Murty MS. Effect of macrolide on pityriasis rosea in comparison with acyclovir. J of Evolution of Med and Dent Sci. 2015;4(27):4689–94.

Al-Timimi G, Al-Mashhadani S, Al-Waiz M. Doxycycline in pityriasis rosea: placebo- controlled clinical trial. J Fac Med Baghdad. 2007;49(1):5.

Anderson CR. Dapsone treatment in a case of vesicular pityriasis rosea. The Lancet 1971;298(7722):493.

Sonthalia S, Kumar A, Zawar V, Priya A, Yadav P, Srivastava S, et al. Double-blind randomized placebocontrolled trial to evaluate the efficacy and safety of short-course low-dose oral prednisolone in pityriasis rosea. J Dermatolog Treat. 2018;29(6):617–22.

Jairath V, Mohan M, Jindal N, Gogna P, Monnappa P, Kaur S, et al. Narrowband UVB phototherapy in pityriasis rosea. Indian Dermatol Online J. 2015;6(5):326.

Castanedo-Cazares JP, Lepe V, Moncada B. Should we still use phototherapy for pityriasis rosea? Photodermatol Photoimmunol Photomed. 2003;19(3):160–1.

York NR, Jacobe HT. UVA1 phototherapy: a review of mechanism and therapeutic application: UVA1 phototherapy. Int J Dermatol. 2010;49(6):623–30.

Lim SH, Kim SM, Oh BH, Ko JH, Lee YW, Choe YB, et al. Low-dose ultraviolet A1 phototherapy for treating pityriasis rosea. Ann Dermatol. 2009;21(3):230.

Ebert M, Otsuka M. Treatment of pityriasis rosea by the injection of thyphoid vaccine. JAMA 1943;123(16):1036–7.

Contreras-Ruiz J, Peternel S, Jiménez Gutiérrez C, Culav-Koscak I, Reveiz L, Silbermann- Reynoso M de L. Interventions for pityriasis rosea. [Internet]. Cochrane Database of Systematic Reviews. 2019 [cited 20 September 2021]. Available at:https://doi.wiley.com/10.1002/14651858.CD005068.pub3

Pedrazini MC, Groppo FC. L-lysine therapy to control the clinical evolution of pityriasis rosea: clinical case report and literature review. Dermatologic Ther. 2021;34(1):1-6.

Diterbitkan

01-11-2024

Unduhan

Data unduhan tidak tersedia.

Cara Mengutip

[1]
Terapi Terkini Pityriasis Rosea. MEDICINUS 2024;37:67-7. https://doi.org/10.56951/72h6tw89.