Kromoblastomikosis Penyakit Jamur yang Terabaikan

Danu Yuliarto; Achmad Satya Negara; Harijono Kariosentono; Nugrohoaji Dharmawan; Nurrachmat Mulianto

doi:10.56951/medicinus.v36i1.116

Kromoblastomikosis Penyakit Jamur yang Terabaikan

Penulis

Danu Yuliarto Departemen Dermatologi dan Venereologi, Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, Surakarta
Achmad Satya Negara Departemen Dermatologi dan Venereologi, Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, Surakarta
Harijono Kariosentono Departemen Dermatologi dan Venereologi, Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, Surakarta
Nugrohoaji Dharmawan Departemen Dermatologi dan Venereologi, Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, Surakarta
Nurrachmat Mulianto Departemen Dermatologi dan Venereologi, Fakultas Kedokteran Universitas Sebelas Maret, RSUD Dr. Moewardi, Surakarta

DOI:

https://doi.org/10.56951/medicinus.v36i1.116

Kata Kunci:

Kromoblastomikosis, penyakit terabaikan, sel muriform

Abstrak

Kromoblastomikosis merupakan infeksi jamur profunda pada kulit dan jaringan subkutan yang disebabkan oleh jamur berpigmen atau jamur dematiaceous. Penyakit ini merupakan endemi di daerah tropis dan subtropis seperti Asia, Afrika, dan Amerika Latin. Kromoblastomikosis lebih banyak ditemukan pada laki-laki dewasa yang bekerja di area pertanian, tukang kebun, maupun tukang kayu. Diagnosis kromoblastomikosis ditegakkan melalui pemeriksaan kerokan kulit, kultur mikroskopik, atau ditemukan sel muriform atau medlar bodies pada pemeriksaan histopatologi maupun kultur. Gambaran klinis bervariasi, lesi awal berupa papul yang menyebar secara lambat selama beberapa bulan sampai tahun, kemudian lesi akan membentuk suatu plak dengan bagian tengah atropi. Banyak pasien tidak terdiagnosis pada tahap awal perkembangan penyakit dikarenakan tahap ini jarang terlihat. Pengobatan kromoblastomikosis meliputi pembedahan lesi awal dan terapi farmakologis dengan agen antifungal seperti itraconazole, yang paling umum digunakan dalam pengobatan kromoblastomikosis. Prognosis kromoblastomikosis tidak terlalu baik, kecuali pada lesi yang baru.

Unduhan

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Referensi

Telles FQ, Hoog SD, Santos DWCL, Salgado CG, Vicente VA, Bonifaz A, et al. Chromoblastomycosis. Clin Microbiol Rev. 2017;30:233-76. DOI: https://doi.org/10.1128/CMR.00032-16

Hay RJ. Deep fungal infections. Dalam Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K, editors. Fitzpatrick’s Dermatology in General Medicine. McGraw Hill; 2012.h.2312–7.

Telles FQ, Esterre P, Blanco MP, Vitale RG, Salgado CG, Bonifaz A. Chromoblastomycosis: an overview of clinical manifestations, diagnosis and treatment. Medical Mycology 2009;47:3-15. DOI: https://doi.org/10.1080/13693780802538001

Schwartz RA, Baran E. Chromoblastomycosis. Available at: http://emedicine.medscape.com/article/1092695-print

Telles FQ. Chromoblastomycosis: A neglected tropical disease. Rev. Inst. Med. Trop. Sao Paulo 2015;57(19):46-50. DOI: https://doi.org/10.1590/S0036-46652015000700009

Hoz RML, Baddley JW. Subcutaneous Fungal Infections. Curr Infect Dis Rep. 2012 14:530–9. DOI: https://doi.org/10.1007/s11908-012-0275-3

Hoog GSD, Telles FQ, Haase G, Zeppenfeldt GF, Angelis DA, Ende AHGGV, et al. Black fungi: clinical and pathogenic approaches. Medical Mycology 2000;38(1):243–50. DOI: https://doi.org/10.1080/mmy.38.1.243.250

Sousa MGT, Azevedo CMPS, Nascimento RC, Ghosn EEB, Santiago KL, Noal V, et al. Fonsecaea pedrosoi infection induces differential modulation of costimulatory molecules and cytokines in monocytes from patients with severe and mild forms of chromoblastomycosis. Journal of Leukocyte Biology 2008;84:864-70. DOI: https://doi.org/10.1189/jlb.0308211

Brun S, Zumelzu C, Hoanganh MB, Levy A, Hermoso DG, Laroche L, et al. First case of chromoblastomycosis from Bangladesh. Medical Mycology 2015;10:1–3. DOI: https://doi.org/10.1016/j.mmcr.2015.08.001

Ameen M. Chromoblastomycosis: clinical presentation and management. Clin and Exp Dermatol. 2009;34:849–54. DOI: https://doi.org/10.1111/j.1365-2230.2009.03415.x

Samaila M, Abdullahi K. Cutaneus Manifestation of Deep Mycosis: An Experience in a Tropical Pathology Laboratory. Indian J Dermatol. 2011;56(3):282-6. DOI: https://doi.org/10.4103/0019-5154.82481

Kim M, Lee S, Sung H, Won C, Chang S, Lee M, et al. Clinical Analysis of Deep Cutaneous Mycoses: A 12-year experience at a single institution. Mycoses 2012;55:501-6. DOI: https://doi.org/10.1111/j.1439-0507.2012.02191.x

Tracoso A, Bava J. Chromoblastomycosis. New England Journal Medicine 2009;361:22. DOI: https://doi.org/10.1056/NEJMicm0807060

Francisco GB, Eduardo G. Cutaneus Tuberculosis. Clinics in Dermatology 2007;25:173–80. DOI: https://doi.org/10.1016/j.clindermatol.2006.05.005

Esterre P, Jahevitra M, Andriantsimahavandy A. Humoral immune response in chromoblastomycosis during and after therapy. Clin Diagn Lab Immunol. 2000;7:497–500. DOI: https://doi.org/10.1128/CDLI.7.3.497-500.2000

Esterre P, Andriantsimahavandy A, Raharisolo C. Natural history of chromoblastomycosis in Madagascar and the Indian Ocean. Bull SocPathol Exot. 1997;90:312–7.

Vidal MS, Castro LG, Cavalcante SC, Lacaz CS. Highly specific and sensitive, immunoblot-detected 54 kDa antigen from Fonsecaea pedrosoi. Med Mycol. 2004;42:511–5. DOI: https://doi.org/10.1080/13693780310001654337

Ahsan MK, Al Attas KM, Buraik MA, Al-Sheikh AM, dan Bajawi SM. Hidden under a cauliflower-like growth: A case of cutaneous chromoblastomycosis and response to combination therapy. Journal of Dermatology & Dermatologic Surgery 2017;21(2):81-3. DOI: https://doi.org/10.1016/j.jdds.2016.11.001

Kazemi A. An Overview on the Global Frequency of Superficial Cutaneous Mycoses and Deep Mycoses. Jundishapour J Microbiol. 2013;6(3):202-4. DOI: https://doi.org/10.5812/jjm.10725

Castro LGM, Pimentel ERA, Lacaz CS. Treatment of chromomycosis by cryosurgery with liquid nitrogen: 15 years’ experience. International Journal of Dermatology 2003;42:408–12. DOI: https://doi.org/10.1046/j.1365-4362.2003.01532.x

Gimenes VMF, Criado PR, Martins JEC, Almeida SR. Cellular immune response of patients with chromoblastomycosis undergoing antifungal therapy. Mycopathologia. 2006;162:97–101. DOI: https://doi.org/10.1007/s11046-006-0041-x

Bonifaz A, Paredes-Solis V, Saul A. Treating chromoblastomycosis with systemic antifungals. A current review of physical and antifungal therapies for chromoblastomycosis. Expert Opin Pharmacother. 2004;5:247–54. DOI: https://doi.org/10.1517/14656566.5.2.247

Pavlidakey GP, Snow SN, Mohs FE. Chromoblastomycosis treated by Mohs micrographic surgery. J Dermatol Surg Oncol. 1986;12:1073–5. DOI: https://doi.org/10.1111/j.1524-4725.1986.tb02085.x

Bonifaz A, Martínez-Soto E, Carrasco-Gerard E, Peniche J. Treatment of chromoblastomycosis with itraconazole, cryosurgery and combination of both. Int J Dermatol. 1997;36:542–7. DOI: https://doi.org/10.1046/j.1365-4362.1997.00085.x

Bonifaz A, Saul A, Paredes-Solis V, Araiza J, Fierro-Arias L. Treatment of chromoblastomycosis with terbinafine: experience with four cases. J Dermatolog Treat. 2005;16:47-51. DOI: https://doi.org/10.1080/09546630410024538