Profile of Candidiasis Patients in RSUD Dr Moewardi Surakarta January 2016-December 2019

Nurrachmat Mulianto; Siti Efrida Fiqnasyani

doi:10.56951/medicinus.v35i2.97

Profile of Candidiasis Patients in RSUD Dr Moewardi Surakarta January 2016-December 2019

Penulis

Nurrachmat Mulianto Dermatovenereology Department, Medical Faculty of University of Sebelas Maret/ Dr.Moewardi Hospital, Surakarta, Central Java, Indonesia
Siti Efrida Fiqnasyani Dermatovenereology Department, Medical Faculty of University of Sebelas Maret/ Dr.Moewardi Hospital, Surakarta, Central Java, Indonesia

DOI:

https://doi.org/10.56951/medicinus.v35i2.97

Kata Kunci:

kandidiasis, KOH, profil pasien

Abstrak

Latar Belakang: Kandidiasis adalah penyakit yang disebabkan oleh infeksi Candida sp., terutama Candida albicans. Kandidiasis dapat terjadi pada kulit, membran mukosa, kuku, dan saluran pencernaan, dengan risiko yang lebih tinggi pada orang dengan gangguan sistem imun. Tujuan: Mengetahui profil penderita kandidiasis di RSUD Dr. Moewardi Surakarta periode Januari 2016-Desember 2019. Metode: Penelitian deskriptif retrospektif ini mengkaji jenis kelamin, usia, diagnosis primer, penyakit penyerta, dan distribusi tipe kandidiasis di RSUD Dr. Moewardi. Hasil: Selama periode studi, terdapat 177 pasien kandidiasis, di mana 147 pasien menjalani rawat jalan dan 30 menjalani rawat inap. Pseudohyphae ditemukan pada semua tes KOH pasien rawat inap. Mayoritas pasien kandidiasis berjenis kelamin wanita (77,97%), dengan distribusi usia yang bervariasi pada pasien rawat jalan dan rawat inap. Kandidiasis kulit ditemukan pada 53,74% pasien rawat jalan dan 66,67% pasien rawat inap. Diabetes melitus tipe 2 merupakan komorbiditas yang paling banyak ditemukan (20%) pada pasien kandidiasis. Terapi antifungal yang digunakan adalah miconazole 2% topikal yang diberikan pada 42,37% pasien serta fluconazole sistemik 150 mg yang diberikan pada 33,90% pasien.

Unduhan

Baca Selengkapnya

Referensi

Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, et al. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2015 Dec;62(4):e1–50. DOI: https://doi.org/10.1093/cid/civ933

Ramaly L. Dermatomikosis Superfisialis. In: Widaty S, editor. Ilmu Penyakit Kulit dan Kelamin. 7th ed. Jakarta: Balai Penerbit FK UI; 2013.p.117–20.

Kristóf K, Janik L, Komka K, Harmath Á, Hajdú J, Nobilis A. Clinical microbiology of neonatal candidiasis in Hungary. Acta Microbiol Immunol Hung. 2010;57(4):407–17. DOI: https://doi.org/10.1556/AMicr.57.2010.4.7

Bongomin F, Gago S, Oladele RO, Denning DW. Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision. J fungi. 2017;3(4):57. DOI: https://doi.org/10.3390/jof3040057

Xiao M, Chen SC, Kong F, Fan X, Cheng J-W, Hou X, et al. Five-year China Hospital Invasive Fungal Surveillance Net (CHIFNET) study of invasive fungal infections caused by noncandidal yeasts: species distribution and azole susceptibility. Infect Drug Resist. 2018;11:659–67. DOI: https://doi.org/10.2147/IDR.S173805

Puspitasari A, Kawilarang AP, Ervianty E, Rohiman A. Profil pasien baru kandidiasis. Berk Ilmu Kesehat Kulit dan Kelamin. 2019;31(1):24–34.

Martiastutuik D, Ervianti E, Agusni I. Penyakit Kulit Dan Kelamin. Surabaya: Airlangga University Press; 2016.

Mitchell T. Medical Micology dalam Jawetz, Melnick & Adelberg’s Medical Microbiology. Carroll K, Butel J, Morse S, Mietzner T Ed New York. 2013;671-713.

Curi ALL, Benchimol EI, Israel DVE. Candidiasis. Intraocular Inflamm. 2016;1261–7.

Mitchell T. Medical Micology. In: Carroll K, Butel J, Morse S, Mietzner T, editors. Jawetz, Melnick, & Adelberg’s Medical Microbiology. 26th ed. New York; 2013. p.671–713.

Spampinato C, Leonardi D. Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents. Omri A, editor. Biomed Res Int. 2013;2013:204237. DOI: https://doi.org/10.1155/2013/204237

López-Martínez R. Candidosis, a new challenge. Clin Dermatol. 2010;28:178–84. DOI: https://doi.org/10.1016/j.clindermatol.2009.12.014

Polii SVG, Pandaleke HEJ, Kapantow MG. Profil kandidosis intertriginosa di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R.D. Kandou Manado periode Januari- Desember 2012. 2016;4. DOI: https://doi.org/10.35790/ecl.4.1.2016.11010

Kalista KF, Chen LK, Wahyuningsih R, Rumende CM. Karakteristik Klinis dan Prevalensi Pasien Kandidiasis Invasif di Rumah Sakit Cipto Mangunkusumo. J Peny Dalam. 2017;2(4):56–61. DOI: https://doi.org/10.7454/jpdi.v4i2.104

Adiguna M. Clinics in Dermatology. 3rd ed. Budimulya U, Kuswadji, Bramono K, Menaldi S, Dwihastuti P, Widiaty S eds. DS, editor. Jakarta, Indoneisa: Balai Penerbit FK UI; 2004.p.1–6.

Bramono K, Budimulja U. Epidemiology of onychomycosis in Indonesia: data obtained from three individual studies. Japanese J Med Mycol. 2005;46(3):171–6. DOI: https://doi.org/10.3314/jjmm.46.171

Rahadiyanti D, Ervianti E. Studi retrospektif: karakteristik dermatofitosis. Berk Ilmu Kesehat Kulit dan Kelamin. 2018;30(1):66–72.

Suyoso S, E EE, Sukanto H. Onikomikosis dalam Pedoman Diagnosis Dan Terapi Bagian/ SMF Ilmu Penyakit Kulit Dan Kelamin. Suranaya: Pedoman Diagnosis dan Terapi Bagian/ SMF Ilmu Penyakit Kulit dan Kelamin Universitas Airlangga; 2006.p.79–83.

Soetojo S, Astari L. Profil pasien baru infeksi kandida pada kulit dan kuku. Berk Ilmu Kesehat Kulit dan Kelamin. 2016;28(1):34–41.

Rahmadhani S, Astari L. Profile of new patients with candida infection in skin and nail. Berk Ilmu Kesehatan Kulit dan Kelamin. 2016;28(1):21–9.

Rahadiyanti D, Ervianti E. Studi retrospektif: karakteristik dermatofitosis. Berk Ilmu Kesehat Kulit dan Kelamin. 2018;30(1):66–72.

Wowor S, Pandeleke H, Kapantow M. Profil kandidiasis intertriginosa di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R.D. Kandou Manado Periode Januari - Desember 2013. J e-Clinic. 2016;4(1):446–51. DOI: https://doi.org/10.35790/ecl.4.1.2016.10957

Wahyuningsih R, Tsuboi R, Burhan E, Rusyati L, Ariwatin N, Miranda E. Indonesia Society for Human and Animal Micology Indonesia. In: Programme and Abstract Book The 6th Asia Pacific Society for Medical Mycology (APSMM) Congress. Denpasar: Udayana University Press; 2013.p.122–5.

Rodrigues CF, Rodrigues ME, Henriques M. Candida sp. Infections in Patients with Diabetes Mellitus. J Clin Med. 2019 Jan;8(1):76. DOI: https://doi.org/10.3390/jcm8010076

Raiesi O, Siavash M, Mohammadi F, Chabavizadeh J, Mahaki B, Maherolnaghsh M, et al. Frequency of Cutaneous Fungal Infections and Azole Resistance of the Isolates in Patients with Diabetes Mellitus. Adv Biomed Res. 2017 Jan;6(1):71. DOI: https://doi.org/10.4103/2277-9175.191003

Ponka D, Baddar F. Microscopic potassium hydroxide preparation. Can Fam Physician. 2014 Jan;60(1):57.

Curi ALL, Benchimol EI, Vasconcelos-Santos DV. Candidiasis. In: Intraocular Inflammation. 2016. DOI: https://doi.org/10.1007/978-3-540-75387-2_121

Bhavan PS, Rajkumar R, Radhakrishnan S, Seenivasan C, Kannan S. Culture and Identification of Candida Albicans from Vaginal Ulcer and Separation of Enolase on SDS-PAGE. Int J Biol. 2010 Jan;2(1):84–93. DOI: https://doi.org/10.5539/ijb.v2n1p84

Greenwood D, Slack R, Barer M, Irving W. Medical Microbiology. 18th ed. Edinburgh: Churchill Livingstone Elsevier; 2012.p.60,596,602–4,614–6.

Mutiawati VK. Pemeriksaan Mikrobiologi pada Candida albicans. J Kedokt Syiah Kuala. 2016;16(1):53–63.

Taudorf EH, Jemec GBE, Hay RJ, Saunte DML. Cutaneous candidiasis – an evidence-based review of topical and systemic treatments to inform clinical practice. J Eur Acad Dermatology Venereol. 2019 Oct;33(10):1863–73. DOI: https://doi.org/10.1111/jdv.15782

Qushawy M, Nasr A, Abd-Alhaseeb M, Swidan S. Design, Optimization and Characterization of a Transfersomal Gel Using Miconazole Nitrate for the Treatment of Candida Skin Infections. Pharmaceutics. 2018 Feb;10(1):26. DOI: https://doi.org/10.3390/pharmaceutics10010026

Brescansin EG, Portilho M, Pessine F. Physical and chemical analysis of comercial nystatin. J Heal Sci. 2013;35(2):215–21. DOI: https://doi.org/10.4025/actascihealthsci.v35i2.12769

Pandit J, Garg M, Jain NK. Miconazole nitrate bearing ultraflexible liposomes for the treatment of fungal infection. J Liposome Res. 2014 Jun;24(2):163–9. DOI: https://doi.org/10.3109/08982104.2013.871025

Mikamo H, Matsumizu M, Nakazuru Y, Okayama A, Nagashima M. Efficacy and safety of a single oral 150 mg dose of fluconazole for the treatment of vulvovaginal candidiasis in Japan. J Infect Chemother. 2015 Jul;21(7):520–6. DOI: https://doi.org/10.1016/j.jiac.2015.03.011