Tingkat Perbedaan Serum Nitric Oxide terhadap Derajat Keparahan dan Durasi Psoriasis
DOI:
https://doi.org/10.56951/medicinus.v35i1.84Kata Kunci:
durasi, keparahan, nitric oxide, psoriasis, psoriasis area and severity index (PASI)Abstrak
Psoriasis adalah bagian dari dermatosis eritroskuamosa dengan etiologi yang belum diketahui secara pasti. Nitric oxide (NO) yang merupakan regulator pertumbuhan dan diferensiasi keratinosit diduga memainkan peran kuat dalam patogenesis penyakit ini. Tujuan dari penelitian ini adalah untuk mengetahui tingkat perbedaan kadar serum NO terhadap derajat keparahan dan durasi penyakit psoriasis. Metode: penelitian cross-sectional pada 22 subjek penderita psoriasis vulgaris di Poliklinik Kulit dan Kelamin RS Dr. Moewardi Surakarta periode Mei-September 2018 dengan 22 individu sehat sebagai kontrol. Tingkat keparahan psoriasis pada subjek dinilai berdasarkan psoriasis area severity index (PASI), pemeriksaan laboratorium serum NO darah menggunakan metode Greiss. Analisis data dilakukan menggunakan uji T dan uji Kruskal-Wallis (p<0,05). Terdapat perbedaan yang signifikan antara kelompok serum NO penderita dan kelompok kontrol (p=0,020); tidak ada tingkat perbedaan yang signifikan antara serum NO penderita dan skor PASI serta durasi penyakit. Hal tersebut menunjukan bahwa NO merupakan unsur penting dalam proses inflamasi pada psoriasis, terutama saat kondisi lesi aktif.
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Gudjonsson JE, Elder JT. Psoriasis. In: Goldsmith LA, Kartz SI, Glichre BA, Paller AS, Leffil DJ, Wolff K, editor. Fitzpatrick’s In General Medicine. 8th ed. Vol 1. Amerika Serikat: Mc Graw Hill; 2012. pp.197-231.
El-Rahman SHA, El-Refaei AM. Measurement of Serum Nitric Oxide in Different Types of Psoriasis. Med J Cairo Univ. 2014;82(1):559-65.
Gokhale NR, Belgaumkar VA, Pandit DP, Deshpande S, Damle DK. A study of serum nitric oxide levels in psoriasis. Indian J Dermatol Venereol Leprol. 2005;71:175-8. DOI: https://doi.org/10.4103/0378-6323.16232
Akturk AS, Ozdogan HK, Bayramgurler D, Cekmen MB, Bilen N, Kiran R. Nitric oxide and malondialdehyde levels in plasma and tissue of psoriasis patients. JEADV 2012;26(7):833- 7. DOI: https://doi.org/10.1111/j.1468-3083.2011.04164.x
Kilinc KI, Girgin SG, Ertam I, Alper S, Ozturk G, Yildirim S. Broad-band ultraviolet B phototherapy is associated with elevated serum thiobarbituric acid reactive substance and nitrite-nitrate levels in psoriatic patients. J Eur Acad Dermatol Venereol. 2006;20(10):1226-31. DOI: https://doi.org/10.1111/j.1468-3083.2006.01765.x
Uttjek M, Dufaker M, Nygren L, Stenberg B. Psoriasis care consumption and expectations from a gender perspective in a psoriasis population in northern Sweden. Acta Derm Venereol. 2005;85(6):503–8.
Wirawan EP, Dharmawan N. Profil pasien psoriasis di Poliklinik Kulit dan Kelamin RSUD Dr. Moewardi Surakarta Periode Januari 2012-Desember 2016. 2017.Unpublished.
Bruch-Gerharz D, Fehsel K, Suschek C, Michel G, Ruzicka T, KolbBachofen V. A proinflammatory activity of interleukin 8 in human skin: expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes. J Exp Med. 1996;184:2007–12.
Zalewska A, Wyczolkowska J, Narbutt J. Nitric oxide levels in plasma and fibroblast cultures of psoriasis vulgaris patients. J Dermatol Sci. 2007;48:237-40. DOI: https://doi.org/10.1016/j.jdermsci.2007.06.012
Mahmoud A, Elmaged RA, Fahmy H, Nada H. Estimation of nitric oxide level in psoriatic patients and its correlation with disease severity. Egypt J of Dermatol Venerol. 2013;33(2):71-5. DOI: https://doi.org/10.4103/1110-6530.123952
Orem A, Aliyazicioglu R, Kiran E, Vanizor B, Cimnocodeit G, Deger O. The relationship between nitric oxide production and activity of the disease in patients with psoriasis. Arch Dermatol. 1997;133:1606–7. DOI: https://doi.org/10.1001/archderm.133.12.1606
Zalewska A, Bruch-Gerharz D, Fehsel K, Suschek C, Michel G, Ruzicka T, Kolb Bachofen V. A proinflammatory activity of interleukin 8 in human skin: expression of the inducible nitric oxide synthase in psoriatic lesions and cultured keratinocytes. J Exp Med. 1996;184:2007–12. DOI: https://doi.org/10.1084/jem.184.5.2007
Schmitt J, Wozel G. The psoriasis area and severity index is the adequate criterion to define severity in chronic plaque-type psoriasis. Dermatology. 2005;210194–9. DOI: https://doi.org/10.1159/000083509
Tekin NS, Ilter N, Sancak B, Ozden MG, Gurer MA. Nitric oxide levels in patients with psoriasis treated with methotrexate. Mediators Inflamm. 2006;16043:1-5. DOI: https://doi.org/10.1155/MI/2006/16043
Ormerod AD, Weller R, Copeland P, Benjamin N, Ralston SH, Grabowski P, et al. Detection of nitric oxide and nitric oxide synthases in psoriasis. Arch Dermatol Res. 1998;290:3-8. DOI: https://doi.org/10.1007/s004030050268
Spuls PI, Lecluse L, Poulsen ML, Bos JD, Stern RS, Nijsten T. How Good Are Clinical Severity and Outcome Measures for Psoriasis?: Quantitative Evaluation in a Systematic Review. J Invest Dermatol. 2010;130:933-43. DOI: https://doi.org/10.1038/jid.2009.391
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