Tingkat Perbedaan Serum Nitric Oxide terhadap Derajat Keparahan dan Durasi Psoriasis
DOI:
https://doi.org/10.56951/medicinus.v35i1.84Kata Kunci:
durasi, keparahan, nitric oxide, psoriasis, psoriasis area and severity index (PASI)Abstrak
Psoriasis adalah bagian dari dermatosis eritroskuamosa dengan etiologi yang belum diketahui secara pasti. Nitric oxide (NO) yang merupakan regulator pertumbuhan dan diferensiasi keratinosit diduga memainkan peran kuat dalam patogenesis penyakit ini. Tujuan dari penelitian ini adalah untuk mengetahui tingkat perbedaan kadar serum NO terhadap derajat keparahan dan durasi penyakit psoriasis. Metode: penelitian cross-sectional pada 22 subjek penderita psoriasis vulgaris di Poliklinik Kulit dan Kelamin RS Dr. Moewardi Surakarta periode Mei−September 2018 dengan 22 individu sehat sebagai kontrol. Tingkat keparahan psoriasis pada subjek dinilai berdasarkan psoriasis area severity index (PASI), pemeriksaan laboratorium serum NO darah menggunakan metode Greiss. Analisis data dilakukan menggunakan uji T dan uji Kruskal-Wallis (p<0,05). Terdapat perbedaan yang signifikan antara kelompok serum NO penderita dan kelompok kontrol (p=0,020); tidak ada tingkat perbedaan yang signifikan antara serum NO penderita dan skor PASI serta durasi penyakit. Hal tersebut menunjukan bahwa NO merupakan unsur penting dalam proses inflamasi pada psoriasis, terutama saat kondisi lesi aktif.
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