The Promising Therapeutic Effects of Nigella Sativa


  • Rimenda Sitepu Perkumpulan Disiplin Herbal Medik Indonesia
  • Kirsten Putriani Hartman Perkumpulan Disiplin Herbal Medik Indonesia
  • Yessy Adhi Utami Perkumpulan Disiplin Herbal Medik Indonesia


Kata Kunci:

Nigella sativa, herbal medicine


Medicinal plants can be potential source to improve general health and perhaps for the treatment of various diseases. However, despite the fact that herbal medicine has been used among various civilizations worldwide, scientific research regarding many herbal medicines was still limited. Nigella sativa (N. sativa), commonly known as fennel flower, black caraway, black cumin, jintan hitam, or kalonji, is a widely used medicinal plant that has been used for the treatment of various health problems. N. sativa contains some compounds that are potentially beneficial for health and wellness, particularly thymoquinone (TQ). Studies have shown some therapeutic benefits of N. sativa, however most them require further investigations to evaluate its efficacy and safety profile. This paper provides summary of available studies and reviews of N. sativa, including findings and limitations of the studies.


Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2013;4(177):1-10. DOI:

Majdalawieh A, Fayyad MW. Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review. International Immunopharmacology 2015;28:295-304. DOI:

Tjandrawinata R, Djunarko I, Fenty, Hendra P. Anti-inflammation effects of Bioactive Fraction DLBS0533 Containing Phaleria macrocarpa and Nigella sativa on Animal Model. International Journal of Pharmacy and Pharmaceutical Sciences 2015;7(1):408-11.

Islam M, Guha B, Hosen S, Riaz TA, Shahadat S, da Rocha Sousa L, et al. Nigellalogy: A Review on Nigella sativa. MOJ Bioequivalence & Bioavailability. 2017;3(6):00056. DOI:

Kooti W, Hasanzade-Noohi Z, Sharafi-Ahvazi N, Asadi-Samani M, Ashtary-Larky D. Phytochemistry, Pharmacology and Therapeutic uses of Black Seed (Nigella sativa). Chinese Journal of Natural Medicines 2016;14(10):0732-45. DOI:

Mohtashami A, Entezari MH. Effects of Nigella sativa Supplementation on Blood Parameters and Anthropometric Indices in Adults: A systematic reviews on clinical trial. Journal of Research in Medical Sciences 2018;21:3. DOI:

Keyhanmanesh R, Boskabady MH, Eslamizadeh MJ, Khamneh S, Ebrahimi MA. The Effect of Thymoquinone, the Main Constituent of Nigella sativa on Tracheal Responsiveness and White Blood Cell Count in Lung Lavage of Sensitized Guinea Pig. Planta Med. 2009;76:218-22. DOI:




Data unduhan tidak tersedia.

Cara Mengutip

The Promising Therapeutic Effects of Nigella Sativa. MEDICINUS 2021;34:61-7.