Terapi Probiotik pada Akne Vulgaris
DOI:
https://doi.org/10.56951/medicinus.v34i2.76Kata Kunci:
akne vulgaris, probiotikAbstrak
Akne vulgaris (AV) adalah penyakit inflamasi kronis kulit yang mengenai unit pilosebasea dan mengakibatkan kelainan noninflamasi berupa komedo terbuka (blackhead) dan komedo tertutup (whitehead), serta adanya tanda inflamasi seperti papul, pustul, dan nodul. Banyak faktor yang berkontribusi terhadap patogenesis AV termasuk mikrobioma kulit seperti Propionibacterium acnes (P. acnes) dan Malassezia spp. yang dikaitkan dengan perkembangan AV melalui pengaruhnya terhadap sekresi sebum, pembentukan komedo, dan respons inflamasi. Terapi antibiotik dengan target P. acnes telah lama menjadi terapi utama AV di mana terapi tersebut ternyata dapat memengaruhi komposisi dari mikrobioma kulit. Seiring dengan meningkatnya resistensi antibiotik, pengetahuan tentang mikrobioma kulit yang terkait dengan AV menjadi sangat relevan dan penting untuk menjadi dasar alternatif pilihan terapi AV.
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