Pubertas Prekoks Perifer Isoseksual akibat Juvenille Granulosa Cell Tumor
DOI:
https://doi.org/10.56951/medicinus.v33i3.66Kata Kunci:
pubertas prekoks isoseksual, granulosa cell tumorAbstrak
Pasien seorang anak perempuan berusia 16 bulan dengan pubertas prekoks perifer isoseksual yang disebabkan oleh juvenile granulosa cell tumor dan menjalani operasi dengan tindakan unilateral salpingo-oophorectomy untuk menghentikan gejala pubertas prekoksnya. Penegakan diagnosis berdasarkan pada hasil anamnesis, pemeriksaan fisik, temuan laboratorium, serta pemeriksaan penunjang lainnya yang menggambarkan adanya perkembangan ciri kelamin sekunder sesuai skala Tanner M3P2, adanya massa abdomen, peningkatan kadar estradiol, serta didukung PA suatu juvenile granulosa cell tumor. Pemeriksaan karyotyping mendapatkan hasil normal. Operasi salpingo-oophorectomy sinistra berhasil menurunkan kadar estradiol dan menghentikan menstruasi, sementara ciri kelamin sekunder masih rutin di-follow-up di poliklinik setiap bulannya.
Unduhan
Referensi
Akhtar H, Guha K, Nahar Z. Precocious Puberty : A Case Report. The Journal of Teachers Association RMC [case report]. 2008; 21(2):177-9. DOI: https://doi.org/10.3329/taj.v21i2.3802
Carel JC, Léger J. Precocious Puberty. New England Journal of Medicine. 2008; 358(22):2366-2377. DOI: https://doi.org/10.1056/NEJMcp0800459
Lee PA, Houk CP. Puberty and Its Disorders. In: Lifshitz F, editor. Pediatric Endocrinology. 5 ed. New York: Informa Healthcare USA, Inc; 2007. p. 273-89.
Rapaport R. Pseudoprecocity Due to Lesions of the Ovary. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, editors. NELSON TEXTBOOK OF PEDIATRICS. 18 ed. Philadelphia: Saunders,Elsevier Inc; 2007.
Sanfilippo JS. Neoplasma. In Behrman RE, Kliegman RM, Jenson HB, editors. Nelson Texbook of Pediatrics, 17th ed. Saunders An Imprint of Elsevier Science; 2004
Dorward AM, Shultz KL, Ackert-Bicknell, EicherEM, Beamer WG. High-Resolution Genetic Map ofX-linked Juvenile-Type Granulosa Cell Tumor Susceptibility Genesin Mouse. Cancer Research 2003; 63 : 8197-8202.
Haroon N, Agarwal G, Pandey R, Dabadghao P. Juvenile granulosa cell tumor presenting as isosexual precocious puberty: A case report and review of literature. Indian Journal of Endocrinology and Metabolism [case report]. 2013; 17(1):157-159. DOI: https://doi.org/10.4103/2230-8210.107870
Pectasides D, Pectasides E, Psyrri A. Granulosa cell tumor of the ovary. Cancer Treatment Reviews [review]. 2008; 34(1):1-12. DOI: https://doi.org/10.1016/j.ctrv.2007.08.007
Mava Y, Chinda J, Alhaji M, Nggada H. Childhood ovarian juvenile granulosa cell tumour: a case report and review of literature. Niger J Paed [case report]. 2012; 39(4):199-201. DOI: https://doi.org/10.4314/njp.v39i4.11
Unduhan
Terbitan
Bagian
Diterbitkan
Unduhan
Lisensi
Hak Cipta (c) 2020 Putu Adi Santosa, Anik Widijanti, Hani Susianti, Katherina Alfa Engli
Artikel ini berlisensi Creative Commons Attribution-NonCommercial 4.0 International License.