Smoking, COPD, Infection and Lung Cancer: How Are They Interconnected?


  • Benjamin J. Tanuwihardja RS Borromeous/Tan Clinic, Bandung

Kata Kunci:

smoking, copd, infection, lung cancer


A case of an elderly ex-smoker chronic obstructive pulmonary disease (COPD) patient with controlled type 2 diabetes mellitus (T2DM) as comorbid was followed-up for 10 years. His stable COPD in the course of time slowly declined to multiple acute exacerbation (AE)-COPD and multiple hospital admissions. High-dose systemic corticosteroids given during AE-COPD with prolonged oral steroids continuation led to depressed immunity that ended with severe immunosuppression, causing sepsis and chronic heart failure (CHF) with non-ST elevated myocardial infarction (NSTEMI) and worsening of COPD in his ninth year follow-up. This immunosuppression also triggered the emergence of lung cancer by allowing malignant cell to evade immune surveillance. Fortunately patient is survived and recovered to stable COPD.


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Cara Mengutip

Tanuwihardja BJ. Smoking, COPD, Infection and Lung Cancer: How Are They Interconnected?. MEDICINUS [Internet]. 1 Mei 2020 [dikutip 11 Agustus 2022];33(1):17-2. Tersedia pada: